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apalutamide will lessen the extent or result of triazolam by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of apalutamide, a solid CYP3A4 inducer, with drugs which are CYP3A4 substrates may end up in reduce exposure to these medicines.If unavoidable, watch clients for loss of efficacy Except